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Weight loss · Injectable GLP-1

10 Best Weight Loss Medications of 2026

Compare the leading brands on effectiveness, safety, approved uses and pricing — we've done the heavy lifting.

Last Updated: September 2026

Editor's Choice

Updated September 2026
Most Popular
02
9.6/10 Excellent
28,904 votes

MetaboLean MD

Save up to $150 on your first month

Same price every month

  • Unlimited clinician messaging
  • 1:1 coaching included
  • Microdose plans available
  • FSA and HSA eligible
Visit Site No bundle required
03
9.3/10 Great
24,310 votes

TrimPath

Flat $99/month, same price at every dose

Flat $99/month

  • No bundling required
  • Cancel any time
  • Buy now, pay later available
Visit Site Cancel any time
04
9.0/10 Very Good
19,775 votes

GlucaTrim

Oral GLP-1 tablets from $79/month

Oral tablets from $79/month

  • Daily tablets, no injections
  • No insurance required
  • Free shipping on every order
Visit Site No injections
05
8.6/10 Good
15,208 votes

LeanCourse

Starter month $49, then $129

Starter month $49

  • Dietitian support included
  • Progress tracking app
  • Pause your plan any time
Visit Site Pause any time

Semaglutide from $89 a month, locked for life.

Our top ranked plan holds your rate for as long as you stay on it. No membership fee, no insurance requirement, no step-up at renewal.

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Injectable GLP-1s went from a diabetes drug to the most requested weight loss prescription in about four years, and the market that grew around them is genuinely hard to read. Two providers can advertise the same molecule at prices that differ threefold.

How we rank weight loss treatments

Every provider on this page is assessed on the factors that matter to real customers: total monthly cost, whether a prescription is included, shipping speed, and the range of medications available.

What to look for

  • Transparent pricing — a flat monthly rate with no dose-based increases.
  • Clinician access — ongoing support rather than a single intake form.
  • No lock-in — the ability to cancel or change plans at any time.

Rankings are reviewed monthly and updated as offers change.

Sources

  1. Add your citation for prescription volume here.
  2. Add your citation comparing injectable and oral outcomes here.

This page is general information, not medical advice.

Questions people ask

Do I need a prescription?

Yes. Every provider listed includes the consultation in the sign-up flow at no separate cost, and a licensed clinician reviews your answers before anything ships.

What happens during the online consultation?

You answer a questionnaire covering medical history, current medications and your goals. A clinician reads it and decides whether treatment is appropriate. If it is, they write the prescription and set your delivery schedule.

What are the side effects?

Nausea is the common one, especially in the first weeks and after each dose increase. Injection site irritation and tiredness also come up. Most of it settles — anything severe is a reason to contact your prescriber rather than push through.

What happens to the price after the first month?

This is the number that matters most and the one most often buried. We record the month-four price for every plan on this page, not the introductory rate.